Storage pool diseases illuminate platelet dense granule biogenesis
Platelet dense granules (DGs) are membrane bound compartments that store polyphosphate and small molecules such as ADP, ATP, Ca2+, and serotonin.The release of DG contents plays a central role in platelet aggregation to form a hemostatic plug.Accordingly, congenital deficiencies in the biogenesis of platelet DGs underlie human genetic replica beach