STORAGE POOL DISEASES ILLUMINATE PLATELET DENSE GRANULE BIOGENESIS

Storage pool diseases illuminate platelet dense granule biogenesis

Platelet dense granules (DGs) are membrane bound compartments that store polyphosphate and small molecules such as ADP, ATP, Ca2+, and serotonin.The release of DG contents plays a central role in platelet aggregation to form a hemostatic plug.Accordingly, congenital deficiencies in the biogenesis of platelet DGs underlie human genetic replica beach

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